{"id":116197,"date":"2023-08-21T08:05:02","date_gmt":"2023-08-21T08:05:02","guid":{"rendered":"https:\/\/haberulus.net\/?p=116197"},"modified":"2023-08-21T08:05:02","modified_gmt":"2023-08-21T08:05:02","slug":"o-da-magdur-olmustu-meme-kanserini-tetikleyebilecek-dort-yeni-gen-kesfedildi","status":"publish","type":"post","link":"https:\/\/haberulus.net\/?p=116197","title":{"rendered":"O da ma\u011fdur olmu\u015ftu: Meme kanserini tetikleyebilecek d\u00f6rt yeni gen ke\u015ffedildi"},"content":{"rendered":"

BRCA1 gibi meme kanseriyle ba\u011flant\u0131l\u0131 oldu\u011fu bilinen genlerdeki bir mutasyon, <\/span>mastektomi yapt\u0131rmay\u0131 se\u00e7en Hollywood oyuncusu Angelina Jolie\u2019de meme kanseri riskini art\u0131rm\u0131\u015ft\u0131.<\/span><\/p>\n

Ancak \u015fimdi \u0130ngiltere\u2019deki Cambridge \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, ke\u015ffettikleri d\u00f6rt yeni gen olan MAP3K1, LZTR1, SAMHD1 ve CDKN2A\u2019n\u0131n kad\u0131nlar\u0131n meme kanseri olma olas\u0131l\u0131\u011f\u0131n\u0131 be\u015f kat art\u0131rabilece\u011fini a\u00e7\u0131klad\u0131.<\/p>\n

\"\"<\/p>\n

HER 200 KADINDAN B\u0130R\u0130\u2026<\/b><\/p>\n

Birle\u015fik Krall\u0131k\u2019ta yakla\u015f\u0131k her 200 kad\u0131ndan biri, bu genlerden \u00f6t\u00fcr\u00fc potansiyel olarak risk grubunda bulunuyor.<\/span><\/p>\n

Cambridge \u00dcniversitesi\u2019nden \u00e7al\u0131\u015fmay\u0131 y\u00f6neten Profes\u00f6r Doug Easton, \u201cMeme kanseriyle ba\u011flant\u0131l\u0131 ilk b\u00fcy\u00fck genler, BRCA1 ve BRCA2, hen\u00fcz 1990\u2019larda ke\u015ffedildi, bu y\u00fczden hala bilmedi\u011fimiz \u00e7ok \u015fey var.\u201d<\/span><\/p>\n

\u201c\u015eu anda NHS\u2019de ailesinde meme kanseri \u00f6yk\u00fcs\u00fc olan kad\u0131nlara genetik risklerini anlamak i\u00e7in sunulan kan testleri hayati \u00f6nem ta\u015f\u0131yor ve gelecekte bunlar\u0131 t\u00fcm kad\u0131nlara sa\u011flamak m\u00fcmk\u00fcn olabilir.\u201d<\/span><\/p>\n

\u201cAncak meme kanseri i\u00e7in en \u00f6nemli be\u015f gen bile, kad\u0131nlardaki ailelerinden kal\u0131tsal olarak artan riskin yaln\u0131zca yakla\u015f\u0131k y\u00fczde 10\u2019unu a\u00e7\u0131kl\u0131yor.\u201d<\/span><\/p>\n

\u201cBu da meme kanseri riski daha y\u00fcksek olan binlerce kad\u0131n\u0131 bulmak ve onlara daha s\u0131k tarama sunmak i\u00e7in \u00f6nemli bir ad\u0131m. <\/span>Bu, gelecekteki genetik testleri daha iyi ve daha kesin hale getirecek.\u201d dedi.<\/span><\/p>\n

DAHA FAZLA ARA\u015eTIRMAYA \u0130HT\u0130YA\u00c7 VAR<\/b><\/p>\n

Nature Genetics dergisinde yay\u0131nlanan \u00e7al\u0131\u015fma, meme kanseri olan 26.000\u2019den fazla kad\u0131n\u0131n genlerini inceleyerek, hastal\u0131\u011f\u0131 olmayan 217.000\u2019den fazla kad\u0131n\u0131n genleriyle kar\u015f\u0131la\u015ft\u0131rd\u0131.<\/span><\/p>\n

Ara\u015ft\u0131rmac\u0131lar, v\u00fccudun meme kanserini \u00f6nlemek i\u00e7in \u00f6nemli bir protein \u00fcretmesini durduracak veya proteinin d\u00fczg\u00fcn \u00e7al\u0131\u015fmamas\u0131na neden olacak hatalar\u0131 arad\u0131lar.<\/span><\/p>\n

MAP3K1 adl\u0131 bir gendeki hatan\u0131n, nadir de olsa bir kad\u0131n\u0131n meme kanserine yakalanma riskini be\u015f kat art\u0131rabilece\u011fini tahmin ettiler.<\/span><\/p>\n

Kanada\u2019daki Laval \u00dcniversitesi ile birlikte y\u00fcr\u00fct\u00fclen \u00e7al\u0131\u015fma \u015fu ana kadar yaln\u0131zca d\u00f6rt gen tan\u0131mlad\u0131, ancak 90 kadar yeni genin potansiyel olarak meme kanseriyle ba\u011flant\u0131l\u0131 olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor.<\/span><\/p>\n

Ara\u015ft\u0131rmac\u0131lar, bu 90 genden hangisinin ger\u00e7ekten \u00f6nemli oldu\u011funu belirlemek i\u00e7in daha fazla say\u0131da kad\u0131n \u00fczerinde ara\u015ft\u0131rma yap\u0131lmas\u0131 gerekti\u011fini belirtti.<\/span>
<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0130ngiliz ve Kanadal\u0131 bilim insanlar\u0131n\u0131n meme kanseriyle ba\u011flant\u0131l\u0131 olan d\u00f6rt gen daha ke\u015ffetmesi, yap\u0131lacak kan testiyle risk ta\u015f\u0131yan kad\u0131nlar\u0131n daha kolay tespit edilebilece\u011fini ortaya koydu.<\/p>\n","protected":false},"author":1,"featured_media":116198,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[226,295,209,7414,161],"class_list":["post-116197","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-arastirma","tag-gen","tag-kadin","tag-meme-kanseri","tag-risk"],"_links":{"self":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/116197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116197"}],"version-history":[{"count":1,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/116197\/revisions"}],"predecessor-version":[{"id":116199,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/116197\/revisions\/116199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/media\/116198"}],"wp:attachment":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=116197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=116197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}