News Medical\u2019\u0131n haberine g\u00f6re, Northwestern \u00dcniversitesinden Kim Lewis ve ekibinin yapt\u0131\u011f\u0131 \u00e7al\u0131\u015fmada, \u201cbakteriyel karanl\u0131k madde\u201d isimli organizmay\u0131 b\u00fcy\u00fctmek i\u00e7in geli\u015ftirilen cihazla yeti\u015ftirilmi\u015f bakteriden \u201cClovibactin\u201d ad\u0131 verilen antibiyotik izole edildi.<\/p>\n
Ara\u015ft\u0131rma sonu\u00e7lar\u0131na g\u00f6re, Clovibactin antibiyoti\u011fi geni\u015f aral\u0131ktaki patojenik bakterilere etki ediyor ve farelerde \u201cStaphylococcus aureus\u201d s\u00fcper bakterisini tedavi edebiliyor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lardan Bonn \u00dcniversitesi Profes\u00f6r\u00fc Tanja Schneider liderli\u011findeki bir grup ise Clovibactin’in al\u0131\u015f\u0131lm\u0131\u015f\u0131n d\u0131\u015f\u0131nda bir yok etme mekanizmas\u0131na sahip oldu\u011funu ve h\u00fccre duvar\u0131 olu\u015fumunda gerekli 3 farkl\u0131 molek\u00fcl\u00fc hedef ald\u0131\u011f\u0131n\u0131 ke\u015ffetti.<\/p>\n
Ekip, Clovibactin\u2019in incelenmesi s\u0131ras\u0131nda n\u00fckleer manyetik rezonans (NMR) ad\u0131 verilen \u00f6zel bir teknik kulland\u0131.<\/p>\n
Utrecht \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131ndan Dr Markus Weingarth, Clovibactin\u2019in bakteriden izole edilmesinden dolay\u0131 di\u011fer antibiyotiklerden farkl\u0131 oldu\u011funu belirtirken, patojenik bakterilerin s\u00f6z konusu ilaca kar\u015f\u0131 diren\u00e7 olu\u015fturacak zaman\u0131 olmad\u0131\u011f\u0131n\u0131 kaydetti.<\/p>\n
Weingarth, Clovibactin\u2019in pirofosfat\u0131 s\u0131k\u0131 bir \u015fekilde, \u201cbir kafes gibi\u201d sard\u0131\u011f\u0131n\u0131 belirterek, \u201cClovibactin hedefinin de\u011fi\u015fmez, korunmu\u015f k\u0131sm\u0131na ba\u011fland\u0131\u011f\u0131ndan, bakterilerin buna kar\u015f\u0131 diren\u00e7 geli\u015ftirmesi \u00e7ok daha zor olacakt\u0131r. \u00c7al\u0131\u015fmalar\u0131m\u0131zda da Clovibactin\u2019e kar\u015f\u0131 herhangi bir diren\u00e7 g\u00f6zlemlemedik\u201d ifadelerini kulland\u0131.<\/p>\n
S\u00f6z konusu h\u00fccre lifinin sadece bakteri h\u00fccre zar\u0131nda olu\u015ftu\u011funu, insanlarda g\u00f6r\u00fclmedi\u011fini s\u00f6yleyen Weingarth, \u201cClovibactin\u2019in bakteri h\u00fccrelerine se\u00e7ici olarak zarar verip insan h\u00fccreleri i\u00e7in zararl\u0131 olmamas\u0131n\u0131n nedeni de muhtemelen budur\u201d ifadesini kulland\u0131.<\/p>\n
Weingarth, Clovibactin\u2019in diren\u00e7 geli\u015fimi olmaks\u0131z\u0131n bakteriyel patojenleri \u00f6ld\u00fcren geli\u015fmi\u015f terap\u00f6tiklerin tasar\u0131m\u0131 i\u00e7in bir potansiyele sahip oldu\u011funu kaydetti. (AA)<\/p>\n","protected":false},"excerpt":{"rendered":"
Utrecht, Bonn ve Northeastern \u00fcniversitelerinin, Almanya Enfeksiyon Ara\u015ft\u0131rma Merkezi ve NovoBiotic \u015firketiyle yapt\u0131\u011f\u0131 ortak \u00e7al\u0131\u015fma sonucu bulunan bir antibiyotik, bu ilaca diren\u00e7li s\u00fcper bakterilere kar\u015f\u0131 tedavilerde kullan\u0131labilecek.<\/p>\n","protected":false},"author":1,"featured_media":117734,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[4449,4099],"class_list":["post-117733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-bakteri","tag-hucre"],"_links":{"self":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/117733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=117733"}],"version-history":[{"count":1,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/117733\/revisions"}],"predecessor-version":[{"id":117735,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/117733\/revisions\/117735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/media\/117734"}],"wp:attachment":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=117733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=117733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=117733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}