ABD’de yap\u0131lan ara\u015ft\u0131rmada, kad\u0131nlar\u0131n erkeklere g\u00f6re b\u00f6brek hasar\u0131n\u0131 daha kolay atlatabilece\u011fi ke\u015ffedildi.<\/b><\/p>\n
Duke \u00dcniversitesi\u2019nde fareler \u00fczerinde yap\u0131lan \u00e7al\u0131\u015fma, kad\u0131nlar\u0131n molek\u00fcler seviyede avantaja sahip oldu\u011funu, bunun, kad\u0131nlar\u0131 b\u00f6brek hasar\u0131nda meydana gelen bir h\u00fccre \u00f6l\u00fcm\u00fc t\u00fcr\u00fcnden korudu\u011funu ortaya koydu.<\/span><\/p>\n \u00c7al\u0131\u015fman\u0131n yazar\u0131 Dr. Tomokazu Souma, \u201cB\u00f6brek hastal\u0131klar\u0131 her y\u0131l d\u00fcnyada 850 milyondan fazla insan\u0131 etkiliyor. Dolay\u0131s\u0131yla kad\u0131nlar\u0131n b\u00f6breklerinin neden kronik ve akut hasardan daha fazla korundu\u011funu anlamak \u00f6nemli.\u201d ifadesini kulland\u0131.<\/span><\/p>\n Souma, bulgular\u0131n\u0131n, gelecekte her iki cinsiyette b\u00f6brek hasar\u0131 tedavisinde \u00f6nemli bir rol oynayabilece\u011fini s\u00f6yledi.<\/span><\/p>\n GENET\u0130K ANAL\u0130Z Y\u00d6NTEM\u0130YLE KE\u015eFED\u0130LD\u0130<\/b><\/p>\n \u00c7al\u0131\u015fmada, daha \u00f6nce b\u00f6brek hastal\u0131klar\u0131nda kilit rol oynad\u0131\u011f\u0131 ke\u015ffedilen, demir ve oksidatif strese ba\u011fl\u0131 ortaya \u00e7\u0131kan ferroptoz adl\u0131 bir \u00e7e\u015fit h\u00fccre \u00f6l\u00fcm\u00fcne odaklan\u0131ld\u0131.<\/span><\/p>\n Ara\u015ft\u0131rmac\u0131lar fareler \u00fczerinde \u00f6zel bir t\u00fcr genetik analiz y\u00f6ntemi kulland\u0131. \u00c7al\u0131\u015fma s\u0131ras\u0131nda di\u015fi olman\u0131n, \u00f6zel bir yolla ferroptoza kar\u015f\u0131 \u00e7arp\u0131c\u0131 bir \u015fekilde koruma sa\u011flad\u0131\u011f\u0131 ke\u015ffedildi.<\/span><\/p>\n Yine kad\u0131nlarda bu \u00f6zel yolun \u00e7ok aktif oldu\u011fu, erkeklerde ise testosteron hormonunun, bu yolun aktivitesini azaltt\u0131\u011f\u0131, bunun da ferroptozu kolayla\u015ft\u0131rd\u0131\u011f\u0131 ve b\u00f6brek hasar\u0131nda h\u00fccre direncini baltalad\u0131\u011f\u0131 tespit edildi.<\/span><\/p>\n Ara\u015ft\u0131rman\u0131n bulgular\u0131, Cell Reports dergisinde yay\u0131nland\u0131. (AA)<\/span><\/p>\n \u00a0<\/p>\n \u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":" ABD’de yap\u0131lan ara\u015ft\u0131rmada, kad\u0131nlar\u0131n erkeklere g\u00f6re b\u00f6brek hasar\u0131n\u0131 daha kolay atlatabilece\u011fi ke\u015ffedildi. Duke \u00dcniversitesi\u2019nde fareler …<\/p>\n","protected":false},"author":1,"featured_media":53776,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[4096],"class_list":["post-53775","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-bobrek"],"_links":{"self":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/53775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53775"}],"version-history":[{"count":1,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/53775\/revisions"}],"predecessor-version":[{"id":53777,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/53775\/revisions\/53777"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/media\/53776"}],"wp:attachment":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=53775"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=53775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}