{"id":83079,"date":"2023-04-29T09:51:03","date_gmt":"2023-04-29T09:51:03","guid":{"rendered":"https:\/\/haberulus.net\/?p=83079"},"modified":"2023-04-29T09:51:03","modified_gmt":"2023-04-29T09:51:03","slug":"sigir-aort-damarindan-3d-yaziciyla-dogal-insan-aort-damari","status":"publish","type":"post","link":"https:\/\/haberulus.net\/?p=83079","title":{"rendered":"S\u0131\u011f\u0131r aort damar\u0131ndan 3D yaz\u0131c\u0131yla do\u011fal insan aort damar\u0131"},"content":{"rendered":"

Ankara \u00dcniversitesi Kimya B\u00f6l\u00fcm\u00fc Biyokimya Anabilim Dal\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. Burak Derku\u015f ile\u00a0y\u00fcksek lisans ve doktora \u00f6\u011frencilerinden olu\u015fan ekibi, \u0130ngiltere\u2019nin Nottingham Universitesi, \u0130svi\u00e7re\u2019den AO Ara\u015ft\u0131rma Enstit\u00fcs\u00fc ile Orta Do\u011fu Teknik \u00dcniversitesi ve \u00c7anakkale Onsekiz Mart \u00dcniversitesi ara\u015ft\u0131rmac\u0131lar\u0131 ile i\u015f birli\u011finde, s\u0131\u011f\u0131r aort damarlar\u0131ndan insanda kullan\u0131labilecek do\u011fal aort damar\u0131 \u00fcretti.<\/p>\n

Kesimhanelerden elde edilen s\u0131\u011f\u0131r aort damarlar\u0131,\u00a0laboratuvar ortam\u0131nda \u2018desel\u00fclerizasyon\u2019 teknolojisiyle h\u00fccrelerinden ar\u0131nd\u0131r\u0131larak, yenilik\u00e7i bir biyomalzemeye d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcp, 3D biyoyaz\u0131c\u0131 arac\u0131l\u0131\u011f\u0131yla yeni aort damarlar\u0131 olu\u015fturuldu. Elastik bir yap\u0131ya sahip yeni aort damarlar\u0131,\u00a0mekanik olarak dayan\u0131kl\u0131 yap\u0131s\u0131n\u0131 yosun kaynakl\u0131 bir biyopolimerden, \u00fcst\u00fcn biyolojik \u00f6zelliklerini ise h\u00fccresizle\u015ftirilmi\u015f aort dokusundan ald\u0131.<\/p>\n

\u2018Y\u00dcZDE Y\u00dcZ DO\u011eAL AORT DAMARI TASARLADIK\u2019<\/strong><\/p>\n

Do\u00e7. Dr. Burak Derku\u015f, aort damar\u0131n\u0131n kalpten \u00e7\u0131kan ve v\u00fccuttaki di\u011fer t\u00fcm atardamarlar\u0131 besleyen en b\u00fcy\u00fck damar oldu\u011funu belirtti. Do\u00e7. Dr. Derku\u015f, aort damar\u0131n\u0131n bir insan \u00f6mr\u00fcnde ortalama 200 milyon litre kan\u0131n aktar\u0131m\u0131ndan sorumlu oldu\u011funu ifade ederek, \u015funlar\u0131 s\u00f6yledi:<\/p>\n

*\u00d6zellikle sa\u011fl\u0131ks\u0131z beslenme, sigara kullan\u0131m\u0131 ya da genetik ge\u00e7i\u015fli hastal\u0131klardan dolay\u0131 bazen aort daralmas\u0131 gibi problemler ortaya \u00e7\u0131kabilmektedir. Bu t\u00fcr durumlar ileri a\u015famalara ge\u00e7erse ve \u00f6zellikle cerrahi i\u015flemlere gereksinim duyulursa, burada sentetik aort greftleri ya da damar vask\u00fcler greftler kullan\u0131lmaktad\u0131r. Bunlar da bir aort damar\u0131n\u0131n g\u00f6sterdi\u011fi biyolojik aktiviteyi ya da fonksiyonu g\u00f6sterememektedir.<\/p>\n

*Bizim \u00e7\u0131k\u0131\u015f noktam\u0131z buras\u0131yd\u0131. Biz ekibimizle birlikte sentetik aort greftlerine alternatif y\u00fczde y\u00fcz do\u011fal, aort damar\u0131n\u0131n kendisinden \u00fcretebilen ultra elastik, diki\u015flenebilir, s\u0131zd\u0131rmaz aort greftlerini tasarlad\u0131k.<\/p>\n

*Y\u00fczde y\u00fcz do\u011fal ve aort dokusunun kendisinin kullan\u0131m\u0131yla ve 3 boyutlu bas\u0131m teknolojisinin getirdi\u011fi avantajlar\u0131 da kullanarak orijinal bir aort damar\u0131n\u0131n geometri ve boyutlar\u0131n\u0131 da g\u00f6z \u00f6n\u00fcnde bulundurarak aort damar e\u015f de\u011ferleri \u00fcretimini ger\u00e7ekle\u015ftirdik.<\/p>\n

\"\"<\/p>\n

\u20183 BOYUTLU BASIM TEKNOLOJ\u0130S\u0130N\u0130 KULLANIYORUZ\u2019<\/strong><\/p>\n

*Burada ilk olarak aort dokusunu temizliyoruz. Ard\u0131ndan k\u00fc\u00e7\u00fck par\u00e7alara ay\u0131r\u0131yoruz ve \u00e7e\u015fitli kimyasallar\u0131n, deterjanlar\u0131n ya da enzimlerin kullan\u0131m\u0131yla bu aort dokular\u0131n\u0131 h\u00fccrelerinden ar\u0131nd\u0131r\u0131yoruz. Ayr\u0131ca n\u00fckleer materyallerden de ar\u0131nd\u0131r\u0131yoruz.<\/p>\n

*Amac\u0131m\u0131z hem hasarl\u0131 h\u00fccrelerinden hem de imm\u00fcn yan\u0131t olu\u015fturmamas\u0131 i\u00e7in n\u00fckleer materyallerinden ar\u0131nd\u0131r\u0131lm\u0131\u015f bir aort dokusunun geri kalan baz k\u0131sm\u0131n\u0131 yani biyokimyasal k\u0131sm\u0131n\u0131 koruyarak elde etmektir.<\/p>\n

*Ard\u0131ndan bunlar\u0131 3 boyutlu bas\u0131m teknolojisi ile yeniden i\u015fleyip yeni aort e\u015f de\u011ferleri \u00fcretiliyor. Daha sonra bunlar k\u00f6k h\u00fccreler ya da hastan\u0131n kendi h\u00fccreleri ile yeniden canland\u0131r\u0131larak, canland\u0131r\u0131lm\u0131\u015f bir biyoyapay aort damar\u0131 elde ediliyor.<\/p>\n

\u2018\u0130NSAN KL\u0130N\u0130\u011e\u0130N\u0130N KULLANIMI \u00d6N\u00dcNDE H\u0130\u00c7B\u0130R ENGEL YOKTUR\u2019<\/strong><\/p>\n

\u00c7al\u0131\u015fman\u0131n insanlarda kullan\u0131labilece\u011fini belirten Do\u00e7. Dr. Derku\u015f, \u201d<\/p>\n

*S\u0131\u011f\u0131r kaynakl\u0131 doku e\u015f de\u011ferlerinin insan klini\u011finin kullan\u0131m\u0131 \u00f6n\u00fcnde hi\u00e7bir engel yoktur. Biz hen\u00fcz preklinik a\u015famaday\u0131z. Geli\u015ftirdi\u011fimiz aort damarlar\u0131n\u0131n ileri derecede damar olu\u015fumunu te\u015fvik etti\u011fini g\u00f6rd\u00fck. Ayr\u0131ca inflamasyon olu\u015fturmad\u0131\u011f\u0131n\u0131 da tespit ettik.<\/p>\n

*Hidrodinamik mekanik dayan\u0131m anlam\u0131nda \u00fcst\u00fcn \u00f6zelliklere sahip. Mekanik dayan\u0131kl\u0131l\u0131\u011f\u0131 son derece y\u00fcksek, elastik, diki\u015flenebilir yani klinik i\u00e7in gerekli kriterleri sa\u011flamaktad\u0131r. Fakat elbette bu s\u00fcre\u00e7ten sonra biz klini\u011fe ge\u00e7i\u015f faz\u0131nday\u0131z. Bunun i\u00e7in gerekli projelerimizi tasarl\u0131yor ve yaz\u0131yoruz. Bir klinik \u00e7al\u0131\u015fma sonras\u0131nda umar\u0131z ki geli\u015ftirdi\u011fimiz bu aort damarlar\u0131 insan klini\u011finde kardiyovask\u00fcler cerrahide kullan\u0131m potansiyeli bulur.<\/p>\n

*Geli\u015ftirdi\u011fimiz \u00fcr\u00fcn standart bir ticari aort greftinin kullan\u0131m\u0131 ile ayn\u0131 prosed\u00fcrlerden ge\u00e7erek klinikte kullanabilme \u015fans\u0131n\u0131 bulabilir.\u00a0 (DHA)<\/p>\n","protected":false},"excerpt":{"rendered":"

Ankara \u00dcniversitesi’nde, kesimhanelerden elde edilen s\u0131\u011f\u0131r aort damarlar\u0131ndan, 3 boyutlu yaz\u0131c\u0131 ile insanda kullan\u0131labilecek ultra elastik, dikilebilir, s\u0131zd\u0131rmaz y\u00fczde y\u00fcz do\u011fal aort damar\u0131 \u00fcretildi.\u00a0<\/p>\n","protected":false},"author":1,"featured_media":83080,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[11384,4872,500,4118,1624],"class_list":["post-83079","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-aort","tag-doku","tag-insan","tag-kullanimi","tag-yuz"],"_links":{"self":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/83079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=83079"}],"version-history":[{"count":1,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/83079\/revisions"}],"predecessor-version":[{"id":83081,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/83079\/revisions\/83081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/media\/83080"}],"wp:attachment":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=83079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=83079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=83079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}