Avustralya\u2019n\u0131n Queensland \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, \u00f6l\u00fcmc\u00fcl \u00f6r\u00fcmcek zehrini kullanarak yeni bir kalp krizi ilac\u0131 \u00fcretti.<\/b><\/p>\n
Avustralya’da Queensland \u00dcniversitesi’nin (UQ) ila\u00e7 ara\u015ft\u0131rmac\u0131lar\u0131ndan olu\u015fan bir ekip, \u00f6l\u00fcmc\u00fcl \u00f6r\u00fcmcek zehrini kullanarak kalp krizine kar\u015f\u0131 yeni bir tedavi geli\u015ftirdi. \u0130la\u00e7, Avustralya’n\u0131n en zehirli \u00f6r\u00fcmceklerinden biri olan K’gari huni yuval\u0131 \u00f6r\u00fcmce\u011finin zehrinden \u00fcretildi.<\/p>\n
\u015eu anda IB001 olarak adland\u0131r\u0131lan ila\u00e7, bir kalp krizi ya da inme s\u0131ras\u0131nda bedenin g\u00f6nderdi\u011fi ve kalp h\u00fccrelerinin \u00f6lmesine yol a\u00e7an sinyali bloke ederek \u00e7al\u0131\u015f\u0131yor. Yerel bir giri\u015fim arac\u0131l\u0131\u011f\u0131yla s\u00f6z konusu tedaviyi pazarlamay\u0131 planlayan ekip, k\u0131sa bir s\u00fcre \u00f6nce Brisbane merkezli Infensa Bioscience \u015firketinin \u00f6zel yat\u0131r\u0131mc\u0131lardan 23 milyon Avustralya dolar\u0131 (15.6 milyon ABD dolar\u0131) tutar\u0131nda ba\u015flang\u0131\u00e7 fonu almas\u0131n\u0131n ard\u0131ndan ilac\u0131n insan denemelerine de yakla\u015ft\u0131\u011f\u0131n\u0131 ifade etti.<\/p>\n
GELECEK YIL KL\u0130N\u0130K DENEYLER BA\u015eLIYOR<\/b><\/p>\n
Infensa Bioscience \u015firketinin elde etti\u011fi ba\u015flang\u0131\u00e7 deste\u011fi sayesinde ila\u00e7, \u00f6n\u00fcm\u00fczdeki y\u0131l Avustralya’n\u0131n Queensland eyaletinde faz 1 klinik deneylerine ba\u015flamaya haz\u0131rlan\u0131yor.
Tedavinin, Avustralya’n\u0131n k\u0131rsal b\u00f6lgelerinde ya\u015fayan ve en yak\u0131n hastanenin saatlerce uzakl\u0131kta oldu\u011fu bir yerde inme ya da kalp krizi ge\u00e7irebilecek hastalar\u0131 tedavi etmek i\u00e7in \u00f6zellikle yararl\u0131 olaca\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyor.<\/p>\n
Queensland \u00dcniversitesi Molek\u00fcler Biyobilim Enstit\u00fcs\u00fc’nden ekip lideri Profes\u00f6r Glenn King, \u201cAkl\u0131mda fel\u00e7 i\u00e7in yararl\u0131 olaca\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fc\u011f\u00fcm\u00fcz belirli bir ila\u00e7 hedefi vard\u0131 ve bu iyon kanal\u0131nda yer al\u0131yordu. Zehirlerin, bu iyon kanallar\u0131n\u0131n aktivitesini ayarlayan en zengin molek\u00fcl kayna\u011f\u0131 oldu\u011fu ortaya \u00e7\u0131kt\u0131. B\u00f6ylece d\u00fcnyan\u0131n en b\u00fcy\u00fc\u011f\u00fc olan zehir koleksiyonumuza bakmaya ba\u015flad\u0131k. \u015ea\u015f\u0131rt\u0131c\u0131 bir \u015fekilde, en ba\u015far\u0131l\u0131 olan molek\u00fcl yerel bir \u00f6r\u00fcmce\u011fin zehrinden \u00e7\u0131kt\u0131. K’gari huni yuval\u0131 \u00f6r\u00fcmce\u011fi, safla\u015ft\u0131rabildi\u011fimiz ve bu iyon kanal\u0131n\u0131n en iyi k\u00fc\u00e7\u00fck molek\u00fcl inhibit\u00f6r\u00fcnden yakla\u015f\u0131k 50 bin kat daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6sterebildi\u011fimiz harika bir molek\u00fcle sahipti\u201d dedi.<\/p>\n
\u0130LK \u0130LA\u00c7 OLACAK<\/b><\/p>\n
UQ Ba\u015f Ara\u015ft\u0131rma G\u00f6revlisi ve Infensa CEO’su Do\u00e7ent Mark Smythe, geli\u015ftirdikleri ilac\u0131n kalp krizi ya da inmeden kaynaklanan, geri d\u00f6n\u00fc\u015f\u00fcm\u00fc bulunmayan h\u00fccre hasar\u0131n\u0131 \u00f6nleme yetene\u011fine sahip d\u00fcnyadaki ilk ila\u00e7 olaca\u011f\u0131n\u0131 ifade etti.<\/p>\n
Smythe \u201cKalp, kalp krizi s\u0131ras\u0131nda \u00f6len kas h\u00fccrelerini yeniden \u00fcretemez, bu nedenle bu zararlar kal\u0131c\u0131 hasar b\u0131rak\u0131r ve kalp yetmezli\u011fi, sakatl\u0131k ve ya\u015fam kalitesinde d\u00fc\u015f\u00fc\u015fe yol a\u00e7abilir\u201d ifadesini kulland\u0131.<\/p>\n
Queensland \u00dcniversitesi’nden ara\u015ft\u0131rmaya katk\u0131da bulunan Nathan Palpant, \u201cBu, ilk m\u00fcdahalede bulunan\u0131n, bir kalp krizi ya da inme ge\u00e7irdi\u011fi d\u00fc\u015f\u00fcn\u00fclen bir hastayla kar\u015f\u0131la\u015ft\u0131\u011f\u0131nda ger\u00e7ekten en erken a\u015famada verebilece\u011fi bir ila\u00e7. (\u015eu anda) Doktorlar\u0131n bu t\u00fcr hasarlar\u0131n daha en ba\u015ftan olu\u015fmas\u0131n\u0131 \u00f6nlemesini sa\u011flayacak bir ila\u00e7 bulunmuyor\u201d diye konu\u015ftu.<\/p>\n
\u015eirket ilac\u0131n, organ nakli i\u00e7in don\u00f6rler taraf\u0131ndan ba\u011f\u0131\u015flanan kalplerin ya\u015fam s\u00fcresini uzatmak amac\u0131yla kullan\u0131m\u0131n\u0131 geni\u015fletmek i\u00e7in kaynak olu\u015fturmaya \u00e7al\u0131\u015f\u0131yor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Avustralya\u2019n\u0131n Queensland \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar, \u00f6l\u00fcmc\u00fcl \u00f6r\u00fcmcek zehrini kullanarak yeni bir kalp krizi ilac\u0131 \u00fcretti. Avustralya’da …<\/p>\n","protected":false},"author":1,"featured_media":8641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[603,188,1564,2655,2656],"class_list":["post-8640","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-avustralya","tag-bas","tag-ilac","tag-kalp-krizi","tag-molekul"],"_links":{"self":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/8640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8640"}],"version-history":[{"count":1,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/8640\/revisions"}],"predecessor-version":[{"id":8642,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/posts\/8640\/revisions\/8642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=\/wp\/v2\/media\/8641"}],"wp:attachment":[{"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haberulus.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}